@article{85326,
  keywords = {Nodal, Pitx2, cell migration, Cilia, left{\textendash}right asymmetry, Morphogenesis},
  author = {Daniel Grimes and Rebecca Burdine},
  title = {Left-Right Patterning: Breaking Symmetry to Asymmetric Morphogenesis.},
  abstract = {<p>Vertebrates exhibit striking left-right (L-R) asymmetries in the structure and position of the internal organs. Symmetry is broken by motile cilia-generated asymmetric fluid flow, resulting in a signaling cascade - the Nodal-Pitx2 pathway - being robustly established within mesodermal tissue on the left side only. This pathway impinges upon various organ primordia to instruct their side-specific development. Recently, progress has been made in understanding both the breaking of embryonic L-R symmetry and how the Nodal-Pitx2 pathway controls lateralized cell differentiation, migration, and other aspects of cell behavior, as well as tissue-level mechanisms, that drive asymmetries in organ formation. Proper execution of asymmetric organogenesis is critical to health, making furthering our understanding of L-R development an important concern.</p>},
  year = {2017},
  journal = {Trends in genetics : TIG},
  volume = {33},
  pages = {616-628},
  month = {09/2017},
  issn = {0168-9525},
  doi = {10.1016/j.tig.2017.06.004},
  language = {eng},
}